Article
Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas.
Science translational medicine - 24 Jun 2015
Wang Yuxuan, Springer Simeon, Mulvey Carolyn L, Silliman Natalie, Schaefer Joy, Sausen Mark, James Nathan, Rettig Eleni M, Guo Theresa, Pickering Curtis R, Bishop Justin A, Chung Christine H, Califano Joseph A, Eisele David W, Fakhry Carole, Gourin Christine G, Ha Patrick K, Kang Hyunseok, Kiess Ana, Koch Wayne M, Myers Jeffrey N, Quon Harry, Richmon Jeremy D, Sidransky David, Tufano Ralph P, Westra William H, Bettegowda Chetan, Diaz Luis A, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Agrawal Nishant
Abstract excerpt
To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93 HNSCC patients. We searched for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% of 47 patients. The fractions of patients with detectable tumor DNA...
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