Tumor heterogeneity in autophagy-dependent ferroptosis

Abstract excerpt

Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependent form of regulated cell death, is not related to autophagy. Conversely, recent evidence indicates that the molecular machinery of autophagy facilitates ferroptosis...

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