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Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer

10 Jun 2021

Abstract excerpt

Ferroptosis is an iron-dependent form of cell death associated with the accumulation of labile iron and cytotoxic lipid peroxides. Increasing evidence reveals that ferroptosis is not a self-standing phenomenon and has close connections with other cellular events. Remarkably, recent insights show that ferroptosis is dependent on autophagy, which is a lysosomal degradation pathway responsible for the recycling of...

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PMID: 34110079
DOI: 10.1002/cmdc.202100334

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