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Mechanism of targeting the mTOR pathway to regulate ferroptosis in NSCLC with different EGFR mutations

1 May 2024

Abstract excerpt

Patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR)-activating mutations can be treated with EGFR-tyrosine kinase inhibitors (TKIs). Although EGFR-TKI-targeted drugs bring survival promotion in patients with EGFR mutations, drug resistance is inevitable, so it is urgent to explore new treatments to overcome drug resistance. In addition, wild-type EGFR lacks targeted...

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PMID: 38751752
DOI: 10.3892/ol.2024.14431

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