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Article

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma

19 May 2021

Abstract excerpt

Abstract MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma (NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly contributes to tumor progression and therapeutic resistance. However, the relationship between MYCN and cell death remains elusive. Ferroptosis is a newly identified cell death mode featured by lipid peroxide accumulation...

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PMID: 34011924
DOI: 10.1038/s41419-021-03790-w

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