Article

Inhibitor of apoptosis, IAP, genes play a critical role in the survival of HIV-infected macrophages

2019-02-06

Abstract excerpt

Latent viral reservoirs of HIV-1 that persist despite antiretroviral therapy (ART) are major barriers for a successful cure. Macrophages serve as viral reservoirs due to their resistance to apoptosis and HIV-cytopathic effects. We have previously shown that inhibitor of apoptosis proteins (IAPs) confer resistance to HIV-Vpr-induced apoptosis in normal macrophages. Herein, we show that second mitochondrial activato...

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Literature Corpus work: a5d8438b-1450-53fc-96d7-ca9cae1d6bee
DOI: 10.1101/543017

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