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Article

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages.

Scientific reports - 25 Nov 2021

Caballero Ramon Edwin, Dong Simon Xin Min, Gajanayaka Niranjala, Ali Hamza, Cassol Edana, Cameron William D, Korneluk Robert, Tremblay Michel J, Angel Jonathan B, Kumar Ashok

Abstract excerpt

Macrophages serve as viral reservoirs due to their resistance to apoptosis and HIV-cytopathic effects. We have previously shown that inhibitor of apoptosis proteins (IAPs) confer resistance to HIV-Vpr-induced apoptosis in normal macrophages. Herein, we show that second mitochondrial activator of caspases (SMAC) mimetics (SM) induce apoptosis of monocyte-derived macrophages (MDMs) infected in vitro with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34824340
DOI: 10.1038/s41598-021-02146-w
PMCID: PMC8617210

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