Article
An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2022
Fucikova Jitka, Hensler Michal, Kasikova Lenka, Lanickova Tereza, Pasulka Josef, Rakova Jana, Drozenova Jana, Fredriksen Tessa, Hraska Marek, Hrnciarova Tereza, Sochorova Klara, Rozkova Daniela, Sojka Ludek, Dundr Pavel, Laco Jan, Brtnicky Tomas, Praznovec Ivan, Halaska Michael J, Rob Lukas, Ryska Ales, Coosemans An, Vergote Ignace, Cibula David, Bartunkova Jirina, Galon Jérôme, Galluzzi Lorenzo, Spisek Radek
Abstract excerpt
PURPOSE: The successful implementation of immune checkpoint inhibitors (ICI) in the clinical management of various solid tumors has raised considerable expectations for patients with epithelial ovarian carcinoma (EOC). However, EOC is poorly responsive to ICIs due to immunologic features including limited tumor mutational burden (TMB) and poor lymphocytic infiltration. An autologous dendritic cell (DC)-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.