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Article

Unique immune characteristics and differential anti-PD-1-mediated reinvigoration potential of CD8+ TILs based on BRCA1/2 mutation status in epithelial ovarian cancers.

Journal for immunotherapy of cancer - 4 Jul 2024

Park Junsik, Kim Jung Chul, Lee Yong Jae, Kim Sunghoon, Kim Sang Wun, Shin Eui-Cheol, Lee Jung Yun, Park Su-Hyung

Abstract excerpt

BACKGROUND: We aimed to investigate the distinct immunological characteristics of the tumor immune microenvironment in epithelial ovarian cancer (EOC) according to BRCA1/2 mutations status and differential PD-1 expression levels. METHODS: Tumor-infiltrating lymphocytes (TILs) were collected from patients with newly diagnosed advanced-stage EOC (YUHS cohort, n=117). This YUHS cohort was compared with The Cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38964784
DOI: 10.1136/jitc-2024-009058
PMCID: PMC11227838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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