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Article

Effects of CYP2D6, CYP3A5, and ABCB1 gene polymorphisms on the pharmacokinetics of two risperidone long-acting injection microsphere formulations.

Progress in neuro-psychopharmacology & biological psychiatry - 13 Jul 2021

Ma Lingyue, Xiang Qian, Zhao Nan, Hu Changqing, Fang Meng, Tan Yunlong, Chen Song, Wang Zining, Liu Pinglan, Sun Kaoxiang, Li Youxin, Wu Fuxi, Tian Hongjun, Fang Maosheng, Zhao Xia, Wang Gang, Cui Yimin

Abstract excerpt

BACKGROUND: LY03004, a novel investigational risperidone long-acting injection (LAI) microsphere formulation, can release risperidone more quickly after injection than Risperdal Consta®. This study aimed to investigate the effects of genetic polymorphisms on the pharmacokinetics of LY03004 compared with those on Risperdal Consta®. METHODS: A total of 100 Chinese patients with stable schizophrenia were randomly...

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Identifiers

PMID: 33400943
DOI: 10.1016/j.pnpbp.2020.110241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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