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Article

Genotyping as a Key Element of Sample Size Optimization in Bioequivalence of Risperidone Tablets.

European journal of drug metabolism and pharmacokinetics - 1 Aug 2018

Chen Ying, Deng Yang, Yan Miao, Hou Zhenyan, Li Yao, Zhang Bikui, Cai Hualin

Abstract excerpt

BACKGROUND AND OBJECTIVES: Risperidone is a derivative of benzisoxazole and is widely used for schizophrenia and other psychiatric illnesses in both adults and children. Previous studies have confirmed that it is a highly variable drug (within-subject variability ≥ 30%). To reduce the large sample size required for bioequivalence researches on highly variable drugs, a role for genotyping in the design of the...

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Identifiers

PMID: 29404931
DOI: 10.1007/s13318-017-0459-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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