Article
Recurrent and Non-Recurrent Copy Number Variants in Native Americans and a Cosmopolitan Sample in Relation to Alcohol Use Disorder and Other Psychiatric Diseases.
Molecular neurobiology - 23 Mar 2026
Wakil Salma M, Morisaki Keita, Shen Pei-Hong, Sucich Dylan G, Schwandt Melanie, Hejtmancik James Fielding, Marietta Cheryl, Yuan Qiaoping, Diazgranados Nancy, Hodgkinson Colin A, Goldman David
Abstract excerpt
Copy number variants (CNVs) can alter disease susceptibility by gene deletion, duplication, and other mechanisms, and have been implicated in neuropsychiatric diseases. However, their rarity or de novo nature impedes linkage analysis. Therefore, we identified recurrent CNVs (rCNVs) in Native Americans with low genetic admixture and high prevalence of alcohol use disorder (AUD) and other psychiatric disorders....
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