A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.

doi:10.1016/j.ebiom.2024.105086

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A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.

EBioMedicine - 1 May 2024

Jennings Mariela V, Martínez-Magaña José Jaime, Courchesne-Krak Natasia S, Cupertino Renata B, Vilar-Ribó Laura, Bianchi Sevim B, Hatoum Alexander S, Atkinson Elizabeth G, Giusti-Rodriguez Paola, Montalvo-Ortiz Janitza L, Gelernter Joel, Artigas María Soler, Elson Sarah L, Edenberg Howard J, Fontanillas Pierre, Palmer Abraham A, Sanchez-Roige Sandra

Abstract excerpt

BACKGROUND: Alcohol consumption is associated with numerous negative social and health outcomes. These associations may be direct consequences of drinking, or they may reflect common genetic factors that influence both alcohol consumption and other outcomes. METHODS: We performed exploratory phenome-wide association studies (PheWAS) of three of the best studied protective single nucleotide polymorphisms (SNPs) in...

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PMID: 38580523
DOI: 10.1016/j.ebiom.2024.105086
PMCID: PMC11121167

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ADH1B
ADH1C

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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