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Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans

11 Dec 2015

Abstract excerpt

Aging in Caenorhabditis elegans is characterized by widespread physiological and molecular changes, but the mechanisms that determine the rate at which these changes occur are not well understood. In this study, we identify a novel link between reproductive aging and somatic aging in C. elegans. By measuring global age-related changes in the proteome, we identify a previously uncharacterized group of secreted...

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PMID: 26656270
DOI: 10.1371/journal.pgen.1005725

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