Article
Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression.
Journal of the National Cancer Institute - 1 Apr 2014
Dews Michael, Tan Grace S, Hultine Stacy, Raman Pichai, Choi Jaewoo, Duperret Elizabeth K, Lawler Jack, Bass Adam, Thomas-Tikhonenko Andrei
Abstract excerpt
BACKGROUND: The c-Myc oncoprotein is activated in the majority of colorectal cancers (CRCs), whereas the TGF-β pathway is frequently affected by loss-of-function mutations, for example in SMAD2/3/4 genes. The canonical model places Myc downstream of inhibitory TGF-β signaling. However, we previously demonstrated that Myc also inhibits TGF-β signaling through the miR-17~92 microRNA cluster, raising the question...
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