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Article

Pinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies.

BMC medical genomics - 28 Dec 2020

Li Binze, Dong Julian, Yu Jiaqi, Fan Yuqi, Shang Lulu, Zhou Xiang, Bai Yongsheng

Abstract excerpt

BACKGROUND: Understanding gene regulation is important but difficult. Elucidating tissue-specific gene regulation mechanism is even more challenging and requires gene co-expression network assembled from protein-protein interaction, transcription factor and gene binding, and post-transcriptional regulation (e.g., miRNA targeting) information. The miRNA binding affinity could therefore be changed by SNP(s) located...

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PMID: 33371893
DOI: 10.1186/s12920-020-00830-w
PMCID: PMC7771066

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