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Article

Significant impact of miRNA-target gene networks on genetics of human complex traits.

Scientific reports - 1 Mar 2016

Okada Yukinori, Muramatsu Tomoki, Suita Naomasa, Kanai Masahiro, Kawakami Eiryo, Iotchkova Valentina, Soranzo Nicole, Inazawa Johji, Tanaka Toshihiro

Abstract excerpt

The impact of microRNA (miRNA) on the genetics of human complex traits, especially in the context of miRNA-target gene networks, has not been fully assessed. Here, we developed a novel analytical method, MIGWAS, to comprehensively evaluate enrichment of genome-wide association study (GWAS) signals in miRNA-target gene networks. We applied the method to the GWAS results of the 18 human complex traits from >1.75...

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Identifiers

PMID: 26927695
DOI: 10.1038/srep22223
PMCID: PMC4772006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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