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Article

A resource for integrated genomic analysis of the human liver.

Scientific reports - 7 Sept 2022

Zhou Yi-Hui, Gallins Paul J, Etheridge Amy S, Jima Dereje, Scholl Elizabeth, Wright Fred A, Innocenti Federico

Abstract excerpt

In this study, we generated whole-transcriptome RNA-Seq from n = 192 genotyped liver samples and used these data with existing data from the GTEx Project (RNA-Seq) and previous liver eQTL (microarray) studies to create an enhanced transcriptomic sequence resource in the human liver. Analyses of genotype-expression associations show pronounced enrichment of associations with genes of drug response. The...

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PMID: 36071064
DOI: 10.1038/s41598-022-18506-z
PMCID: PMC9452507

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