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Article

LOXL2 upregulates hypoxia‑inducible factor‑1α signaling through Snail‑FBP1 axis in hepatocellular carcinoma cells.

Oncology reports - 1 May 2020

Fan Zhiyong, Zheng Wei, Li Hui, Wu Wujun, Liu Xiaogang, Sun Zhongjie, Hu Haitian, Du Lixue, Jia Qingan, Liu Qingguang

Abstract excerpt

Lysyl oxidase‑like 2 (LOXL2), a member of the lysyl oxidase gene family, is involved in the progression of hepatocellular carcinoma progression and metastasis. Increased expression of LOXL2 has been identified in several types of cancer, including hepatocellular carcinoma. Recently, LOXL2 has been reported to promote epithelial‑mesenchymal transition by reducing E‑cadherin expression via the upregulation of Snail...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32323822
DOI: 10.3892/or.2020.7541
PMCID: PMC7107812

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LOXL2 upregulates hypoxia‑inducible factor‑1α signaling through Snail‑FBP1 axis in hepatocellular carcinoma cells.PMID 32323822Read ↗

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