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Article

Modeling by disruption and a selected-for partner for the nude locus.

EMBO reports - 3 Mar 2021

Li Jian, Lee Yun-Kyoung, Fu Wenyu, Whalen Anne M, Estable Mario C, Raftery Laurel A, White Kristin, Weiner Lorin, Brissette Janice L

Abstract excerpt

A long-standing problem in biology is how to dissect traits for which no tractable model exists. Here, we screen for genes like the nude locus (Foxn1)-genes central to mammalian hair and thymus development-using animals that never evolved hair, thymi, or Foxn1. Fruit flies are morphologically disrupted by the FOXN1 transcription factor and rescued by weak reductions in fly gene function, revealing molecules that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33369874
DOI: 10.15252/embr.201949804
PMCID: PMC7926259

Genes

AFF4
FOXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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