Article

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysis

2025-05-10

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder associated with a wide range of symptoms, including the formation of tumours along nerves. These tumours can affect nerve function, leading to pain and loss of sensory or motor capacity. Drug treatments are currently limited, and relatively few new targets have emerged for NF1 tumors despite intensive research. Therefore, new drugs to target NF1 -de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f4ba23a-04b3-51e9-875a-8872c798bf91
DOI: 10.1101/2025.05.06.652376

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysisDOI 10.1101/2025.05.06.652376Read

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysisSemantic proximity Read

Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumorsSemantic proximity Read

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumorsSemantic proximity Read

The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.Semantic proximity Read

Cross-Species Insights from ART-D to Uncover Evolutionarily Conserved Oncogenic MechanismsSemantic proximity Read

Neurofibromatosis Type 1 and MEK Inhibition: A Comprehensive Review with Focus on Selumetinib TherapySemantic proximity Read

Mutation-Directed Therapeutics for Neurofibromatosis Type ISemantic proximity Read

Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic TargetSemantic proximity Read

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2Semantic proximity Read

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.Semantic proximity Read

A rapid platform for 3D patient-derived cutaneous neurofibroma organoid establishment and screeningSemantic proximity Read

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors.Semantic proximity Read