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Article

Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos.

The Journal of biological chemistry - 10 Feb 2017

Chen Jing, Wu Xiaotong, Yao Likun, Yan Lu, Zhang Lin, Qiu Juhui, Liu Xingfeng, Jia Shunji, Meng Anming

Abstract excerpt

ADP-ribosylation factor GTPases are activated by guanine nucleotide exchange factors including Gbf1 (Golgi brefeldin A-resistant factor 1) and play important roles in regulating organelle structure and cargo-selective vesicle trafficking. However, the developmental role of Gbf1 in vertebrates remains elusive. In this study, we report the zebrafish mutant line tsu3994 that arises from N-ethyl-N-nitrosourea...

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Identifiers

PMID: 28003365
DOI: 10.1074/jbc.M116.767608
PMCID: PMC5313103

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