Article
Clinical and Molecular Findings in Mendelian Susceptibility to Mycobacterial Diseases: Experience From India.
Frontiers in immunology - 1 Jan 2021
Taur Prasad D, Gowri Vijaya, Pandrowala Ambreen Abdulwahab, Iyengar Vaishnavi V, Chougule Akshaya, Golwala Zainab, Chandak Shraddha, Agarwal Reepa, Keni Purva, Dighe Neha, Bodhanwala Minnie, Prabhu Shakuntala, George Biju, Fouzia N A, Edison Eunice Sindhuvi, Arunachalam Arun Kumar, Madkaikar Manisha Rajan, Dalvi Aparna Dhondi, Yadav Reetika Malik, Bargir Umair Ahmed, Kambli Priyanka Madhav, Rawat Amit, Das Jhumki, Joshi Vibhu, Pilania Rakesh Kumar, Jindal Ankur Kumar, Bhat Sunil, Bhattad Sagar, Unni Jeeson, Radhakrishnan Nita, Raj Revathi, Uppuluri Ramya, Patel Shivani, Lashkari Harsha Prasada, Aggarwal Amita, Kalra Manas, Udwadia Zarir, Bafna Vibha Sanjay, Kanade Tarun, Puel Anne, Bustamante Jacinta, Casanova Jean Laurent, Desai Mukesh M
Abstract excerpt
Mendelian Susceptibility to Mycobacterial diseases (MSMD) are a group of innate immune defects with more than 17 genes and 32 clinical phenotypes identified. Defects in the IFN-γ mediated immunity lead to an increased susceptibility to intracellular pathogens like mycobacteria including attenuated Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) vaccine strains and non-tuberculous environmental mycobacteria...
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