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A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Diabetes - 1 Nov 2017

Liu Jun, van Klinken Jan Bert, Semiz Sabina, van Dijk Ko Willems, Verhoeven Aswin, Hankemeier Thomas, Harms Amy C, Sijbrands Eric, Sheehan Nuala A, van Duijn Cornelia M, Demirkan Ayşe

Abstract excerpt

Mendelian randomization (MR) provides us the opportunity to investigate the causal paths of metabolites in type 2 diabetes and glucose homeostasis. We developed and tested an MR approach based on genetic risk scoring for plasma metabolite levels, utilizing a pathway-based sensitivity analysis to control for nonspecific effects. We focused on 124 circulating metabolites that correlate with fasting glucose in the...

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Blood Glucose
Diabetes Mellitus, Type 2
ERF gene
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Mendelian Randomization Analysis

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PMID: 28847883
DOI: 10.2337/db17-0199

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ERF

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