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Article

Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis.

Journal of the American Chemical Society - 13 Jan 2021

Tsunematsu Yuta, Maeda Naoya, Sato Michio, Hara Kodai, Hashimoto Hiroshi, Watanabe Kenji, Hertweck Christian

Abstract excerpt

Epidithiodiketopiperazines (ETPs) are a class of ecologically and medicinally important cyclodipeptides bearing a reactive transannular disulfide bridge. Aspirochlorine, an antifungal and toxic ETP isolated from Aspergillus oryzae used in sake brewing, deviates from the common ETP scaffold owing to its unusual ring-enlarged disulfide bridge linked to a spiroaminal ring system. Although this disulfide ring system...

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Identifiers

PMID: 33351612
DOI: 10.1021/jacs.0c08879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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