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Article

A core metabolic enzyme mediates resistance to phosphine gas.

Science (New York, N.Y.) - 9 Nov 2012

Schlipalius David I, Valmas Nicholas, Tuck Andrew G, Jagadeesan Rajeswaran, Ma Li, Kaur Ramandeep, Goldinger Anita, Anderson Cameron, Kuang Jujiao, Zuryn Steven, Mau Yosep S, Cheng Qiang, Collins Patrick J, Nayak Manoj K, Schirra Horst Joachim, Hilliard Massimo A, Ebert Paul R

Abstract excerpt

Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and...

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PMID: 23139334
DOI: 10.1126/science.1224951

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DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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