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Article

Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis.

The Journal of biological chemistry - 21 Apr 2017

Park Hyun Bong, Sampathkumar Parthasarathy, Perez Corey E, Lee Joon Ha, Tran Jeannie, Bonanno Jeffrey B, Hallem Elissa A, Almo Steven C, Crawford Jason M

Abstract excerpt

Members of the gammaproteobacterial Photorhabdus genus share mutualistic relationships with Heterorhabditis nematodes, and the pairs infect a wide swath of insect larvae. Photorhabdus species produce a family of stilbenes, with two major components being 3,5-dihydroxy-4-isopropyl-trans-stilbene (compound 1) and its stilbene epoxide (compound 2). This family of molecules harbors antimicrobial and immunosuppressive...

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PMID: 28246174
DOI: 10.1074/jbc.M116.762542
PMCID: PMC5399116

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