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Global genome mining-driven discovery of an unusual biosynthetic logic for fungal polyketide–terpenoid hybrids

1 Jan 2024

Abstract excerpt

a distinct biosynthetic mechanism from those adopted by known pathways. Characterization of one of the BGCs revealed that it yields the drimane-phthalide hybrid 1. During the biosynthesis of 1, the farnesyl group is unusually introduced by the dimethylallyltryptophan synthase-type prenyltransferase MfmD and is then cyclized by the Pyr4-family terpene cyclase MfmH. The replacement of MfmH with its homologue OcdTC...

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PMID: 38404388
DOI: 10.1039/d3sc06001b

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