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Article

The APOE ε4 allele in relation to pre- and postsurgical cognitive functioning of patients with primary brain tumors.

European journal of neurology - 1 May 2021

Butterbrod Elke, Sitskoorn Margriet, Bakker Marjan, Jakobs Bernadette, Fleischeuer Ruth, Roijers Janine, Rutten Geert-Jan, Gehring Karin

Abstract excerpt

BACKGROUND: Recent studies suggest a relationship between the APOE ε4 allele and cognitive outcome in patients treated for malignant brain tumors. Still, longitudinal investigations that include a pretreatment cognitive assessment are lacking and APOE's effects in patients with benign tumors are understudied. This study investigated presurgical cognitive performance and postsurgical change in ε4-carrying and...

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PMID: 33342004
DOI: 10.1111/ene.14693
PMCID: PMC8247965

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