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Article

Impact of Apolipoprotein E Genotype on Neurocognitive Function in Patients With Brain Metastases: An Analysis of NRG Oncology's RTOG 0614.

International journal of radiation oncology, biology, physics - 1 Jul 2024

Wefel Jeffrey S, Deshmukh Snehal, Brown Paul D, Grosshans David R, Sulman Erik P, Cerhan Jane H, Mehta Minesh P, Khuntia Deepak, Shi Wenyin, Mishra Mark V, Suh John H, Laack Nadia N, Chen Yuhchyau, Curtis Amarinthia Amy, Laba Joanna M, Elsayed Ahmed, Thakrar Anu, Pugh Stephanie L, Bruner Deborah W

Abstract excerpt

PURPOSE: Whole-brain radiation therapy (WBRT) is a common treatment for brain metastases and is frequently associated with decline in neurocognitive functioning (NCF). The e4 allele of the apolipoprotein E (APOE) gene is associated with increased risk of Alzheimer disease and NCF decline associated with a variety of neurologic diseases and insults. APOE carrier status has not been evaluated as a risk factor for...

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Identifiers

PMID: 38101486
DOI: 10.1016/j.ijrobp.2023.12.004
PMCID: PMC11162903

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APOE

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