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Article

CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction.

European journal of clinical pharmacology - 1 May 2021

Weckwerth Giovana M, Dionísio Thiago J, Costa Yuri M, Colombini-Ishiquiriama Bella L, Oliveira Gabriela M, Torres Elza A, Bonjardim Leonardo R, Calvo Adriana M, Moore Troy, Absher Devin M, Santos Carlos F

Abstract excerpt

PURPOSE: This study hypothesized that drugs accumulate in the bloodstream of poor-metabolizing patients and may have more adverse effects and different pain perceptions and aimed to investigate the influence of CYP450 polymorphisms on acute postoperative pain, swelling, and trismus controlled by ibuprofen (600 mg) in 200 volunteers after dental extraction. In addition, surgical outcomes can determine pain, edema,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33205280
DOI: 10.1007/s00228-020-03046-0

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