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Polyglutamine expanded Ataxin-7 induces DNA damage and alters FUS localization and function

16 Dec 2020

Abstract excerpt

Polyglutamine (polyQ) diseases, such as Spinocerebellar ataxia type 7 (SCA7), are caused by expansions of polyQ repeats in disease specific proteins. The sequestration of vital proteins into aggregates formed by polyQ proteins is believed to be a common pathological mechanism in these disorders. The RNA-binding protein FUS has been observed in polyQ aggregates, though if disruption of this protein plays a role in...

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PMID: 33338633
DOI: 10.1016/j.mcn.2020.103584

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