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Article

Self-assembled FUS binds active chromatin and regulates gene transcription.

Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2014

Yang Liuqing, Gal Jozsef, Chen Jing, Zhu Haining

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Fused in sarcoma (FUS) is a DNA/RNA binding protein and mutations in FUS cause a subset of familial ALS. Most ALS mutations are clustered in the C-terminal nuclear localization sequence of FUS and consequently lead to the accumulation of protein inclusions in the cytoplasm. It remains debatable whether loss of FUS normal function in...

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Identifiers

PMID: 25453086
DOI: 10.1073/pnas.1414004111
PMCID: PMC4273402

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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