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Article

Self-assembled FUS binds active chromatin and regulates gene transcription.

Proceedings of the National Academy of Sciences of the United States of America - 16 Dec 2014

Yang Liuqing, Gal Jozsef, Chen Jing, Zhu Haining

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Fused in sarcoma (FUS) is a DNA/RNA binding protein and mutations in FUS cause a subset of familial ALS. Most ALS mutations are clustered in the C-terminal nuclear localization sequence of FUS and consequently lead to...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25453086
DOI: 10.1073/pnas.1414004111
PMCID: PMC4273402

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25453086-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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