TET2 promotes monocyte inflammatory activation in asthma via ALKBH5-m6A regulation and PI3K signaling: evidence from m6A-SNP and single-cell analyses.

doi:10.1007/s00438-026-02497-x

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Article

TET2 promotes monocyte inflammatory activation in asthma via ALKBH5-m6A regulation and PI3K signaling: evidence from m6A-SNP and single-cell analyses.

Molecular genetics and genomics : MGG - 9 Sept 2026

Wang Zun, Wang Qian, Sa Yuqin, Ma Nan, Wang Shuo, Huang Chongmei, Liu Minhui, Tang Siyuan

Abstract excerpt

Asthma is a complex inflammatory airway disease with strong genetic determinants, yet the functional relevance of most asthma-associated non-coding variants remains unclear. Emerging evidence suggests that N6-methyladenosine (m6A) modification may serve as a critical epitranscriptomic link between genetic variation and immune regulation. In this study, we aimed to systematically identify functionally relevant...

Read the complete abstract on PubMed

Topics

Humans
Dioxygenases
Asthma
Proto-Oncogene Proteins
DNA-Binding Proteins
Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Monocytes

Signal Transduction

Adenosine

RNA Methylation

AlkB Homolog 5, RNA Demethylase

Epitranscriptome

Single-Cell Analysis

Inflammation

Epitranscriptomics

Genome-Wide Association Study

Source

Open in PubMed

Identifiers

PMID: 42714648
DOI: 10.1007/s00438-026-02497-x

Genes

TET2
ALKBH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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