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Epigenomic and proteomic analyses provide insights into early-life immune regulation and asthma development in infants

14 Apr 2025

Abstract excerpt

Infants with severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies in a multi-ethnic cohort of these infants. We identify 61 differentially methylated regions in infant blood (<1 year of age) associated with recurrent wheezing by age 3 (170 cases, 318 non-cases) and/or asthma by age 6 (112...

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PMID: 40229234
DOI: 10.1038/s41467-025-57288-6

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