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Article

Substantial Attenuation of Virulence of Tembusu Virus Strain PS Is Determined by an Arginine at Residue 304 of the Envelope Protein.

Journal of virology - 24 Feb 2021

Yang Lixin, Liang Te, Lv Junfeng, Qu Shenghua, Meng Runze, Yang Baolin, Feng Chonglun, Dai Weiqian, Wang Xiaoyan, Zhang Bing, Zhang Dabing

Abstract excerpt

The Tembusu virus (TMUV) PS strain, derived by several passages and plaque purifications in BHK-21 cells, displays markedly lower virulence in Pekin ducklings relative to a natural isolate of TMUV, but the potential virulence determinants and the in vivo mechanisms for substantial virulence attenuation of the passage variant remain unknown. Here, we constructed a series of chimeric and mutant viruses and assessed...

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Identifiers

PMID: 33328312
DOI: 10.1128/JVI.02331-20
PMCID: PMC8094961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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