Article
Long-term passage of duck Tembusu virus in BHK-21 cells generates a completely attenuated and immunogenic population with increased genetic diversity.
Vaccine - 22 Jan 2020
Zhang Lijiao, Sun Mengxu, Zhang Qingshui, Wang Jun, Cao Yanxin, Cui Shangjin, Su Jingliang
Abstract excerpt
Duck Tembusu virus (TMUV) is an emerging pathogenic flavivirus that causes severe egg-drop and fatal encephalitis in domestic ducks and geese. Although a live-attenuated virus vaccine is effective for disease control, the stability of the attenuation has not been clearly evaluated due to a poor understanding of the attenuation mechanism. Here, a virulent duck TMUV isolate was successively passaged in BHK-21...
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