Article
A quasispecies in a BHK-21 cell-derived virulent Tembusu virus strain contains three groups of variants with distinct virulence phenotypes.
Veterinary microbiology - 1 Dec 2021
Yang Lixin, Liang Te, Lv Junfeng, Qu Shenghua, Meng Runze, Yang Baolin, Feng Chonglun, Li Qiong, Wang Xiaoyan, Zhang Dabing
Abstract excerpt
Previous studies resulted in the isolation of a low-virulence plaque-purified variant from the third passage (P3) in BHK-21 cells of a Tembusu virus (TMUV) isolate, suggesting the presence of viral quasispecies in the P3 culture. To confirm this notion, the fourth passage virus (P4) was prepared by infecting BHK-21 cells with P3 for isolation of more variants. We isolated 10 plaque-purified viruses. Comparative...
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