Article
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.
British journal of cancer - 12 Jul 2016
Jarvis David, Mitchell Jonathan S, Law Philip J, Palin Kimmo, Tuupanen Sari, Gylfe Alexandra, Hänninen Ulrika A, Cajuso Tatiana, Tanskanen Tomas, Kondelin Johanna, Kaasinen Eevi, Sarin Antti-Pekka, Kaprio Jaakko, Eriksson Johan G, Rissanen Harri, Knekt Paul, Pukkala Eero, Jousilahti Pekka, Salomaa Veikko, Ripatti Samuli, Palotie Aarno, Järvinen Heikki, Renkonen-Sinisalo Laura, Lepistö Anna, Böhm Jan, Meklin Jukka-Pekka, Al-Tassan Nada A, Palles Claire, Martin Lynn, Barclay Ella, Farrington Susan M, Timofeeva Maria N, Meyer Brian F, Wakil Salma M, Campbell Harry, Smith Christopher G, Idziaszczyk Shelley, Maughan Timothy S, Kaplan Richard, Kerr Rachel, Kerr David, Buchanan Daniel D, Win Aung K, Hopper John L, Jenkins Mark A, Lindor Noralane M, Newcomb Polly A, Gallinger Steve, Conti David, Schumacher Fred, Casey Graham, Taipale Jussi, Aaltonen Lauri A, Cheadle Jeremy P, Dunlop Malcolm G, Tomlinson Ian P, Houlston Richard S
Abstract excerpt
BACKGROUND: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. METHODS: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood...
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