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Article

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator.

International journal of epidemiology - 16 Dec 2024

Lee Matthew A, Hatcher Charlie A, Hazelwood Emma, Goudswaard Lucy J, Tsilidis Konstantinos K, Vincent Emma E, Martin Richard M, Smith-Byrne Karl, Brenner Hermann, Cheng Iona, Kweon Sun-Seog, Le Marchand Loic, Newcomb Polly A, Schoen Robert E, Peters Ulrike, Gunter Marc J, Van Guelpen Bethany, Murphy Neil

Abstract excerpt

BACKGROUND: Adiposity is an established risk factor for colorectal cancer (CRC). The pathways underlying this relationship, and specifically the role of circulating proteins, are unclear. METHODS: Utilizing two-sample univariable Mendelian randomization (UVMR), multivariable Mendelian randomization (MVMR), and colocalization, based on summary data from large sex-combined and sex-specific genetic studies, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39846783
DOI: 10.1093/ije/dyae175
PMCID: PMC11754674

Genes

GREM1

Provenance

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