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Article

Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.

British journal of cancer - 1 Jul 2025

Yuan Fangcheng, Jia Guochong, Wen Wanqing, Xu Shuai, Gunchick Valerie, Deng Kui, Long Jirong, Yu Danxia, Shu Xiao-Ou, Zheng Wei

Abstract excerpt

BACKGROUND: Emerging evidence suggests metabolic dysregulation may contribute to colorectal cancer (CRC) aetiology. We aimed to identify pre-diagnostic metabolic biomarkers for CRC risk in 230,420 UK Biobank participants. METHODS: Nuclear magnetic resonance spectroscopy was used to quantify 249 metabolic biomarkers in plasma samples collected at baseline. Cox proportional hazards models were used to estimate...

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Identifiers

PMID: 40307439
DOI: 10.1038/s41416-025-02997-4
PMCID: PMC12238234

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