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Article

MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons.

International journal of molecular sciences - 21 May 2024

Tokuda Eiichi, Sakashita Yume, Tokoro Naoya, Date Ayano, Kosuge Yasuhiro, Miyasaka Tomohiro

Abstract excerpt

Misfolding of superoxide dismutase-1 (SOD1) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) with SOD1 mutations. The development of antibodies specific for misfolded SOD1 deepens our understanding of how the protein participates in ALS pathogenesis. Since the term "misfolding" refers to various disordered conformers other than the natively folded one, which misfolded species are recognized by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38891791
DOI: 10.3390/ijms25115603
PMCID: PMC11171496

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