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Article

ALS-causing SOD1 mutations promote production of copper-deficient misfolded species.

Journal of molecular biology - 24 Jun 2011

Ip Philbert, Mulligan Vikram Khipple, Chakrabartty Avijit

Abstract excerpt

Point mutations scattered throughout the sequence of Cu,Zn superoxide dismutase (SOD1) cause a subset of amyotrophic lateral sclerosis (ALS) cases. SOD1 is a homodimer in which each subunit binds one copper atom and one zinc atom. Inclusions containing misfolded SOD1 are seen in motor neurons of SOD1-associated ALS cases. The mechanism by which these diverse mutations cause misfolding and converge on the same...

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Source

Identifiers

PMID: 21549128
DOI: 10.1016/j.jmb.2011.04.027

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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