Article
Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya.
Frontiers in cellular and infection microbiology - 1 Jan 2020
Torrevillas Brandi K, Garrison Sarah M, McKeeken Alexander J, Patel Dharmeshkumar, Van Leuven James T, Dizon Nathaniel I, Rivas Karina I, Hathaway Nicholas J, Bailey Jeffrey A, Waitumbi John N, Kifude Carolyne M, Oyieko Janet, Stewart V Ann, Luckhart Shirley
Abstract excerpt
Antifolate resistance is significant in Kenya and presumed to result from extensive use and cross-resistance between antifolate antimalarials and antibiotics, including cotrimoxazole/Bactrim used for HIV-1 chemotherapy. However, little is known about antifolate-resistant malaria in the context of newly diagnosed HIV-1 co-infection prior to administration of HIV-1 chemotherapy. Blood samples from a cross-sectional...
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