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Article

Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya.

Malaria journal - 24 Nov 2010

Spalding Maroya D, Eyase Fredrick L, Akala Hoseah M, Bedno Sheryl A, Prigge Sean T, Coldren Rodney L, Moss William J, Waters Norman C

Abstract excerpt

BACKGROUND: Anti-malarial drug resistance in Kenya prompted two drug policy changes within a decade: sulphadoxine-pyrimethamine (SP) replaced chloroquine (CQ) as the first-line anti-malarial in 1998 and artemether-lumefantrine (AL) replaced SP in 2004. Two cross-sectional studies were conducted to monitor changes in the prevalence of molecular markers of drug resistance over the period in which SP was used as the...

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PMID: 21106088
DOI: 10.1186/1475-2875-9-338
PMCID: PMC3001743

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