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Chikungunya Virus nsP2 Impairs MDA5/RIG-I-Mediated Induction of NF-κB Promoter Activation: A Potential Target for Virus-Specific Therapeutics

15 Dec 2020

Abstract excerpt

Activated IRF3 or IRF7 and NF-B together induce type I interferon (IFN)- production; secreted IFN- binds to IFN receptors and directly activates the Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling pathway to express IFN-stimulated genes (ISGs) However, the pathogenesis of CHIKV infection and the mechanism by which the virus evades the innate immune system remain poorly...

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PMID: 33323678
DOI: 10.4014/jmb.2012.12005

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