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Article

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling.

Journal of virology - 1 Oct 2010

Fros Jelke J, Liu Wen Jun, Prow Natalie A, Geertsema Corinne, Ligtenberg Maarten, Vanlandingham Dana L, Schnettler Esther, Vlak Just M, Suhrbier Andreas, Khromykh Alexander A, Pijlman Gorben P

Abstract excerpt

Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon (IFN). Recent research, however, suggests that alphaviruses may have additional mechanisms to circumvent the host's antiviral IFN...

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Identifiers

PMID: 20686047
DOI: 10.1128/JVI.00949-10
PMCID: PMC2950581

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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