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Chikungunya Virus-Encoded nsP2, E2 and E1 Strongly Antagonize the Interferon- ¥Signaling Pathway

28 Nov 2019

Abstract excerpt

family. It causes multiple symptoms, including headache, fever, severe joint and muscle pain, and arthralgia. Since CHIKV was first isolated in Tanzania in 1952, there have been multiple outbreaks of chikungunya fever. However, its pathogenesis and mechanisms of viral immune evasion have been poorly understood. In addition, the exact roles of individual CHIKV genes on the host innate immune response remain...

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PMID: 31635445
DOI: 10.4014/jmb.1910.10014

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