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Article

HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection.

Immunogenetics - 1 Jul 2016

Buhler Stéphane, Nunes José Manuel, Sanchez-Mazas Alicia

Abstract excerpt

The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present larger repertories of peptides than homozygotes. This seems contradictory, however, with a reduced diversity at...

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Share to Genes, MHC Class I
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-C Antigens

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Share to Quantitative Trait Loci

Share to Receptors, KIR

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Source

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Identifiers

PMID: 27233953
DOI: 10.1007/s00251-016-0918-x
PMCID: PMC4911380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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