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Article

Revisiting the mode of action of the antimalarial proguanil using the yeast model.

Biochemical and biophysical research communications - 1 Jan 2021

Mounkoro Pierre, Michel Thomas, Meunier Brigitte

Abstract excerpt

Proguanil in combination with its synergistic partner atovaquone has been used for malaria treatment and prophylaxis for decades. However its mode of action is not fully understood. Here we used yeast to investigate its activity. Proguanil inhibits yeast growth, causes cell death and acts in synergy with atovaquone. It was previously proposed that the drug would target the system that maintains the mitochondrial...

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Identifiers

PMID: 33316545
DOI: 10.1016/j.bbrc.2020.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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